Novel Approach for the Cyclic Voltammetric Determination of an Antidepressant Drug (Dosulepin) in Pharmaceutical Formulations

Background: This research was focused on the development of a quick, simple, precise, and cost-effective voltammetric method for quantifying dosulepin. Materials Methods: The antidepressant drug (dosulepin) assessed in pharmaceutical formulations using square wave (SWV) Differential pulse (DPV) techniques at glassy carbon potentiometric working electrodes (GCE). Results: Dosulepin demonstrated single clear sharp cathodic peak applied potential -0.7 to -0.75 V versus Ag/AgCl/KCl reference electrode. Results from cyclic voltammetry, DPV, SWV revealed one reduction with pH 7. proposed method’s excellent sensitivity by obtained LOD 7.686 x10- 8 mol L-1and LOQ 2.589x10-7mol L-1bulk were applying Pulse Voltammmetry method. On other hand 1.735x10-7mol 5.785x10-7mol dosulepin achieved Square Wave Voltammetry Conclusion: suggested methods might be recommended usage quantitative detection, product testing, laboratories.